The November 2017 Volume 75 Supplement of the Journal of Biomedical Informatics was a special issue dedicated to the 2016 RDoC for Psychiatry NLP Challenge. Guest editors are challenge organizers Özlem Uzuner, Amber Stubbs, and Michele Filannino. They provide overviews of the challenge and its two main tracks: De-identification and Symptom Severity Classification. 14 teams who participated in the challenge present their results. All 17 articles in the volume are included in our list of Publications.